Matthijs Kox Selected Research

Endotoxemia

1/2021	Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
1/2021	Human in vivo neuroimaging to detect reprogramming of the cerebral immune response following repeated systemic inflammation.
1/2020	Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo.
1/2020	Effect of Vasopressors on the Macro- and Microcirculation During Systemic Inflammation in Humans In Vivo.
2/2019	The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study.
1/2019	Long-Term Effects of Experimental Human Endotoxemia on Immune Cell Function: Similarities and Differences With Sepsis.
1/2019	The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans.
1/2019	Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia.
1/2019	Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model.
1/2019	Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.

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Matthijs Kox Research Topics

Disease

37	Inflammation (Inflammations) 10/2021 - 10/2009
36	Sepsis (Septicemia) 01/2021 - 03/2007
30	Endotoxemia 01/2021 - 09/2009
17	COVID-19 01/2022 - 01/2020
17	Critical Illness (Critically Ill) 10/2021 - 10/2007
10	Septic Shock (Toxic Shock Syndrome) 01/2020 - 07/2013
9	Infections 03/2021 - 03/2014
6	Hypoxia (Hypoxemia) 01/2021 - 05/2014
6	Wounds and Injuries (Trauma) 08/2018 - 01/2015
3	Lymphopenia (Lymphocytopenia) 10/2021 - 12/2019
2	Acute Kidney Injury (Acute Renal Failure) 04/2022 - 01/2021
2	Hyperventilation 12/2021 - 05/2014
2	Pneumonia (Pneumonitis) 10/2021 - 01/2012
2	Coinfection 10/2021 - 01/2021
2	Bacterial Infections (Bacterial Infection) 01/2021 - 01/2017
2	Fever (Fevers) 12/2020 - 01/2019
2	Anemia 01/2015 - 10/2014
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 02/2010 - 02/2009
2	Familial Cerebral Amyloid Angiopathy 02/2010 - 02/2009
2	Alzheimer Disease (Alzheimer's Disease) 02/2010 - 02/2009
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022
1	Hypotension (Low Blood Pressure) 03/2021
1	Peritonitis 03/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2021
1	Non-Muscle Invasive Bladder Neoplasms 01/2021
1	Metabolic Diseases (Metabolic Disease) 01/2021
1	Overweight 01/2021

Drug/Important Bio-Agent (IBA)

30	CytokinesIBA 10/2021 - 01/2011
14	Biomarkers (Surrogate Marker)IBA 04/2022 - 01/2011
14	EndotoxinsIBA 01/2019 - 07/2011
10	Interleukin-10 (Interleukin 10)IBA 01/2019 - 01/2011
8	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022 - 01/2016
8	Interleukin-6 (Interleukin 6)IBA 01/2021 - 02/2009
7	LipopolysaccharidesIBA 01/2020 - 08/2011
7	AdrenomedullinIBA 01/2019 - 12/2014
6	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 10/2021 - 01/2011
5	InterleukinsIBA 01/2021 - 01/2018
5	alanyl-glutaminyl-glycyl-valineIBA 01/2021 - 01/2018
5	enibarcimabIBA 01/2019 - 01/2018
4	HLA-DR Antigens (HLA-DR)IBA 01/2020 - 03/2014
4	Adenosine (Adenocard)FDA LinkGeneric 07/2018 - 09/2012
3	Interferon-gamma (Interferon, gamma)IBA 10/2021 - 03/2014
3	C-Reactive ProteinIBA 10/2021 - 01/2021
3	Oxygen (Dioxygen)IBA 10/2021 - 11/2015
3	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 03/2021 - 01/2018
3	InterferonsIBA 12/2020 - 04/2016
3	Vasopressins (Vasopressin)IBA 01/2020 - 01/2018
3	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2020 - 01/2018
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2013
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 01/2018
3	Hormones (Hormone)IBA 01/2019 - 10/2017
3	HepcidinsIBA 01/2019 - 10/2014
3	Interleukin-8 (Interleukin 8)IBA 01/2019 - 01/2011
3	Mitochondrial DNA (mtDNA)IBA 01/2017 - 01/2016
3	Escherichia coli endotoxinIBA 01/2017 - 01/2014
2	VaccinesIBA 04/2021 - 12/2015
2	Pharmaceutical PreparationsIBA 04/2021 - 01/2018
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021 - 02/2009
2	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2021
2	ProcalcitoninIBA 01/2021 - 01/2011
2	Ferritins (Ferritin)IBA 01/2021 - 12/2020
2	Messenger RNA (mRNA)IBA 01/2021 - 01/2017
2	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2020 - 07/2013
2	CreatinineIBA 01/2020 - 01/2016
2	Iohexol (Omnipaque)FDA Link 01/2020 - 01/2020
2	Peptides (Polypeptides)IBA 01/2019 - 01/2018
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2019 - 01/2017
2	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 01/2019 - 01/2018
2	GlucansIBA 01/2019 - 11/2016
2	Fatty Acid-Binding ProteinsIBA 01/2018 - 02/2015
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017 - 11/2014
2	DNA (Deoxyribonucleic Acid)IBA 04/2016 - 01/2016
2	Epinephrine (Adrenaline)FDA LinkGeneric 04/2016 - 05/2014
2	IronIBA 10/2014 - 03/2014
2	GlucocorticoidsIBA 01/2014 - 09/2009
2	Hydrocortisone (Cortisol)FDA LinkGeneric 06/2012 - 01/2011
2	Amyloid beta-PeptidesIBA 02/2010 - 02/2009
1	AcidsIBA 12/2021
1	Viral RNAIBA 10/2021
1	Adrenergic Agonists (Adrenergic Receptor Agonist)IBA 03/2021
1	AlbuminsIBA 01/2021
1	Triggering Receptor Expressed on Myeloid Cells-1IBA 01/2021
1	tocilizumab (atlizumab)FDA Link 01/2021
1	Immunomodulating AgentsIBA 01/2021
1	Angiotensin-Converting Enzyme 2IBA 01/2021
1	Thyroid HormonesIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	AngiotensinsIBA 01/2021
1	Angiotensin IIIBA 01/2021
1	Testosterone (Sustanon)FDA Link 01/2021

Therapy/Procedure

15	Therapeutics 01/2020 - 06/2013
7	Intravenous Administration 01/2021 - 06/2012
6	Immunotherapy 10/2021 - 06/2013
6	Artificial Respiration (Mechanical Ventilation) 01/2021 - 01/2012
4	Length of Stay 04/2022 - 02/2014
3	Critical Care (Surgical Intensive Care) 01/2018 - 06/2013
3	Meditation 04/2016 - 06/2012
2	Precision Medicine 01/2019 - 01/2017
2	Immunomodulation 01/2016 - 01/2014
2	Vagus Nerve Stimulation 06/2015 - 01/2012